Ryouichi Horie Selected Research

dehydroxymethylepoxyquinomicin

1/2013	Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells.
11/2008	Identification of the RelA domain responsible for action of a new NF-kappaB inhibitor DHMEQ.
11/2007	Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with tax-deficient adult T-cell leukemia-derived cell lines.
8/2005	In vivo antitumor activity of the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin in a mouse model of adult T-cell leukemia.

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Ryouichi Horie Research Topics

Disease

16	Hodgkin Disease (Hodgkin's Disease) 06/2021 - 04/2002
14	Neoplasms (Cancer) 01/2020 - 04/2002
6	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 11/2007 - 05/2005
5	Lymphoma (Lymphomas) 03/2011 - 05/2002
4	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2017 - 04/2004
4	T-Cell Leukemia (Leukemia, T Cell) 11/2007 - 10/2005
2	Liver Diseases (Liver Disease) 01/2021 - 12/2018
2	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2018 - 01/2009
2	B-Cell Lymphoma (Lymphoma, B Cell) 01/2018 - 01/2013
2	Lung Neoplasms (Lung Cancer) 02/2014 - 12/2009
2	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 01/2010 - 11/2002
2	Multiple Myeloma 03/2005 - 07/2004
1	Hypoxia (Hypoxemia) 06/2021
1	Thrombocytopenia (Thrombopenia) 01/2021
1	Inflammation (Inflammations) 09/2019
1	Waldenstrom Macroglobulinemia (Macroglobulinemia) 12/2015
1	Adenocarcinoma of Lung 02/2014
1	Melanoma (Melanoma, Malignant) 01/2013
1	Myeloid Leukemia (Leukemia, Myelocytic) 01/2012
1	Diabetes Mellitus 09/2011
1	Hepatitis B 03/2011
1	Infections 03/2011
1	Hepatitis 03/2011
1	Hypereosinophilic Syndrome (Loeffler Endocarditis) 09/2010
1	Giardiasis 09/2010
1	Disease Progression 01/2010
1	Plasmablastic Lymphoma 01/2010
1	Stomach Neoplasms (Stomach Cancer) 12/2009
1	Colonic Neoplasms (Colon Cancer) 12/2009
1	Oncogene Addiction 12/2009
1	Splenic Infarction 06/2007
1	Jaundice (Icterus) 06/2007
1	Residual Neoplasm 04/2007
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 04/2007
1	Carcinogenesis 01/2006
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 08/2005
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 05/2002

Drug/Important Bio-Agent (IBA)

19	NF-kappa B (NF-kB)IBA 01/2011 - 04/2002
6	Biological ProductsIBA 09/2019 - 01/2003
4	Anaplastic Lymphoma KinaseIBA 01/2017 - 04/2004
4	dehydroxymethylepoxyquinomicinIBA 01/2013 - 08/2005
3	Transcription Factors (Transcription Factor)IBA 01/2013 - 08/2005
2	lusutrombopagIBA 01/2021 - 12/2018
2	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2013
2	Surface Antigens (Surface Antigen)IBA 03/2011 - 08/2005
2	DNA (Deoxyribonucleic Acid)IBA 03/2011 - 08/2005
2	Tumor Biomarkers (Tumor Markers)IBA 08/2005 - 07/2004
1	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2021
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 06/2021
1	Heme Oxygenase-1IBA 06/2021
1	AutoantibodiesIBA 01/2021
1	Thrombopoietin (c-mpl Ligand)IBA 01/2021
1	CytokinesIBA 09/2019
1	CD30 LigandIBA 05/2018
1	MicroRNAs (MicroRNA)IBA 01/2018
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2017
1	JNK Mitogen-Activated Protein KinasesIBA 01/2017
1	Edetic Acid (EDTA)FDA Link 12/2015
1	Brefeldin AIBA 09/2015
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 02/2014
1	Phosphatidylinositols (Phosphatidylinositol)IBA 02/2014
1	Mechanistic Target of Rapamycin Complex 1IBA 02/2014
1	B-Cell Antigen Receptors (B Cell Antigen Receptors)IBA 01/2013
1	Azacitidine (5 Azacytidine)FDA Link 01/2012
1	Sorbitol (Yal)FDA Link 09/2011
1	Glycated Serum AlbuminIBA 09/2011
1	Rituximab (Mabthera)FDA Link 03/2011
1	LigandsIBA 01/2011
1	Metronidazole (Metric)FDA LinkGeneric 09/2010
1	Interleukin-2 Receptors (IL 2 Receptor)IBA 09/2010
1	ParaffinIBA 01/2010
1	Formaldehyde (Formol)FDA Link 01/2010
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 12/2009
1	CamptothecinIBA 12/2009
1	I-kappa B KinaseIBA 12/2009
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 11/2008
1	Imatinib Mesylate (Gleevec)FDA Link 04/2007
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 03/2006
1	Phosphotransferases (Kinase)IBA 09/2005
1	Mitogen-Activated Protein KinasesIBA 09/2005
1	NucleophosminIBA 09/2005
1	Interleukin-6 (Interleukin 6)IBA 08/2005
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2004
1	Oncogene Proteins (Oncogene Protein)IBA 04/2004
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 08/2003
1	Tumor Necrosis Factor Receptor-Associated Peptides and ProteinsIBA 05/2002

Therapy/Procedure

5	Drug Therapy (Chemotherapy) 12/2009 - 11/2002
4	Therapeutics 01/2013 - 10/2005
2	Radiotherapy 01/2010 - 11/2002
2	Splenectomy 01/2009 - 06/2007
1	Ligation 05/2018
1	Patient Admission (Patient Admissions) 06/2007
1	Stem Cell Transplantation 04/2007
1	Chemoprevention 10/2005
1	Salpingo-oophorectomy 11/2002
1	Hysterectomy 11/2002